OraVerse
(phentolamine mesylate) Injection

Phentolamine mesylate is phenol,3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methyl-phenyl)amino]-,methanesulfonate(salt), a non-specific alpha adrenergic blocker.

Phentolamine mesylate USP is a white to off-white,odorless crystalline powder with a molecular weight of 377.46. It is sparinglysoluble in water, soluble in alcohol, and slightly soluble in chloroform. The empiricalformulation is C17H19N3O•CH4O3S,and the chemical structure is:

OraVerse (phentolamine mesylate) Injection is a clear,colorless, sterile, non pyrogenic, isotonic, preservative free solution. Each1.7 mL cartridge contains 0.4 mg phentolamine mesylate, D-mannitol, edetatedisodium, and sodium acetate. Either acetic acid or sodium hydroxide is used asnecessary to adjust the pH.

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"The U.S. Food and Drug Administration today approved Invokana (canagliflozin) tablets, used with diet and exercise, to improve glycemic control in adults with type 2 diabetes.

Type 2 diabetes is the most common form of the disease, affe"...

Jentadueto®
(linagliptin and metformin hydrochloride) Tablets, Film-Coated

Lactic acidosis is a rare,but serious, complication that can occur due to metformin accumulation. Therisk increases with conditions such as renal  impairment, sepsis,dehydration, excess alcohol intake, hepatic impairment, and acute congestiveheart failure.

The onset is often subtle,accompanied only by nonspecific symptoms such as malaise, myalgias, respiratorydistress, increasing somnolence, and nonspecific abdominal distress.

Laboratory abnormalitiesinclude low pH, increased anion gap, and elevated blood lactate.

If acidosis is suspected,JENTADUETO should be discontinued and the patient hospitalized immediately [seeWARNINGS AND PRECAUTIONS].

JENTADUETO tablets contain 2 oral antihyperglycemic drugsused in the management of type 2 diabetes mellitus: linagliptin and metforminhydrochloride.

Linagliptin is an orally-active inhibitor of thedipeptidyl peptidase-4 (DPP-4) enzyme.

Linagliptin is described chemically as 1H-Purine-2,6-dione,8-[(3R)-3-amino-1-piperidinyl]-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2quinazolinyl)methyl]

The empirical formula is C25H28N8O2and the molecular weight is 472.54 g/mol. The structural formula is:

Linagliptin is a white toyellowish, not or only slightly hygroscopic solid substance. It is veryslightly soluble in water (0.9 mg/mL). Linagliptin is soluble in methanol (ca.60 mg/mL), sparingly soluble in ethanol (ca. 10 mg/mL), very slightly solublein isopropanol ( < 1 mg/mL), and very slightly soluble in acetone (ca. 1mg/mL).

Metformin hydrochloride(N,N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically orpharmacologically related to any other classes of oral antihyperglycemicagents. Metformin hydrochloride is a white to off-white crystalline compoundwith a molecular formula of C4H11N5•HCl and amolecular weight of 165.63. Metformin hydrochloride is freely soluble in waterand is practically insoluble in acetone, ether, and chloroform. The pKa ofmetformin is 12.4. The pH of a 1% aqueous solution of metformin hydrochlorideis 6.68. The structural formula is:

JENTADUETO is available fororal administration as tablets containing 2.5 mg linagliptin and 500 mgmetformin hydrochloride (JENTADUETO 2.5 mg/500 mg), 850 mg metforminhydrochloride (JENTADUETO 2.5 mg/850 mg) or 1000 mg metformin hydrochloride(JENTADUETO 2.5 mg/1000 mg). Each film-coated tablet of JENTADUETO contains thefollowing inactive ingredients: arginine, corn starch, copovidone, colloidalsilicon dioxide, magnesium stearate, titanium dioxide, propylene glycol,hypromellose, talc, yellow ferric oxide (2.5 mg/500 mg; 2.5 mg/850 mg) and/orred ferric oxide (2.5 mg/850 mg; 2.5 mg/1000 mg).

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"The costs of caring for people with dementia in the United States in 2010 were between $159 billion to $215 billion, and those costs could rise dramatically with the increase in the numbers of older people in coming decades, according to estimate"...

ARICEPT ®
(donepezil hydrochloride) Tablets

ARICEPT (donepezil hydrochloride) is a reversibleinhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2,3-dihydro-5, 6-dimethoxy2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-onehydrochloride. Donepezil hydrochloride is commonly referred to in thepharmacological literature as E2020. It has an empirical formula of C24H29NO3HCland a molecular weight of 415.96. Donepezil hydrochloride is a whitecrystalline powder and is freely soluble in chloroform, soluble in water and inglacial acetic acid, slightly soluble in ethanol and in acetonitrile andpractically insoluble in ethyl acetate and in n-hexane.

ARICEPT is available for oraladministration in film-coated tablets containing 5, 10, or 23 mg of donepezilhydrochloride.

Inactive ingredients in 5 mgand 10 mg tablets are lactose monohydrate, corn starch, microcrystallinecellulose, hydroxypropyl cellulose, and magnesium stearate. The film coatingcontains talc, polyethylene glycol, hypromellose and titanium dioxide.Additionally, the 10 mg tablet contains yellow iron oxide (synthetic) as acoloring agent.

Inactive ingredients in 23 mgtablets include ethylcellulose, hydroxypropyl cellulose, lactose monohydrate,magnesium stearate and methacrylic acid copolymer, Type C. The film coatingincludes ferric oxide, hypromellose 2910, polyethylene glycol 8000, talc andtitanium dioxide.

ARICEPT ODT tablets areavailable for oral administration. Each ARICEPT ODT tablet contains 5 or 10 mgof donepezil hydrochloride. Inactive ingredients are carrageenan, mannitol,colloidal silicon dioxide and polyvinyl alcohol. Additionally, the 10 mg tabletcontains ferric oxide (yellow) as a coloring agent.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using donepezil and call your doctor at once if you have any of these serious side effects:

Less serious side effects may include:

Read All Potential Side Effects and See Pictures of Aricept »

Before taking donepezil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease), fainting, heart disease (such as sick sinus syndrome, other heart conduction disorder), seizures, stomach/intestinal disease (such as ulcers, bleeding), trouble urinating (such as enlarged prostate).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform...

Read All Potential Precautions of Aricept »

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